Adults with autism spectrum disorders (ASD) show deficits in some aspects of gaze processing, including understanding of the social meaning of gaze, and discriminating small differences between direct and averted gaze in upright faces. Here, we investigated whether the influences of face inversion and facial expression on sensitivity to eye contact are typical in adults with ASD by having high-functioning adults with and without ASD judge whether gaze was direct or averted to the left or right in photographed faces that varied in facial expression and orientation.