Epoxidized natural rubber (ENR) can be used as a compatibilizer in silica-filled natural rubber, as it results in improved filler–rubber interaction, silica dispersion and tensile strength. Increase of ENR content and mole% of epoxide groups increases the interactions between silica and rubber, and decreases filler–filler interaction, as reflected by the lower Mooney viscosity, Payne effect, flocculation rate constant, filler networking factor, and the higher filler–rubber interaction parameter, chemically bound rubber and tensile strength. The addition of ENR-51 at 7.5 phr shows the best overall properties, however still lower when compared to a compound with TESPT silane as coupling agent.