Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition characterized by the occurrence of fragility fractures, most commonly vertebral, in late pregnancy or the early postpartum period. Since its first report in 1948, about 100 cases have been described (1). While the majority of cases have been reported in primagravid women, a substantial number occurred in women who have had a previously uneventful pregnancy (1). The prevalence, etiology and pathogenesis of this osteoporosis are unknown although there are several hypotheses attempting to explain the etiophatogenesis of pregnancy associated osteoporosis. In this paper we present two cases of young women who developed severe PAO with vertebral fractures: a 42-year-old woman with a familial history of osteoporosis, and a 21-year-old woman affected with myasthenia gravis under therapy with glucocorticoids.
Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition characterized by the occurrence of fragility fractures, most commonly vertebral, in late pregnancy or the early postpartum period. Since its first report in 1948, about 100 cases have been described (1). While the majority of cases have been reported in primagravid women, a substantial number occurred in women who have had a previously uneventful pregnancy (1). The prevalence, etiology and pathogenesis of this osteoporosis are unknown although there are several hypotheses attempting to explain the etiophatogenesis of pregnancy associated osteoporosis. In this paper we present two cases of young women who developed severe PAO with vertebral fractures: a 42-year-old woman with a familial history of osteoporosis, and a 21-year-old woman affected with myasthenia gravis under therapy with glucocorticoids.
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