Polydiacetylene (PDA) is an excellent color-changing indicator. In this paper, we demonstrate a new and
interesting kind of time–temperature chromatic sensor based on PDA vesicle and amphiphilic polymer.
In presence of amphiphilic polymers, PDA vesicles could gradually transit from blue to red, which was
irreversible and regularly depended on the temperature, time, and properties of amphiphilic polymer
(including the concentration, molecular weight, molecular structure, hydrophobicity, and thermosensitive
property). Higher concentration of amphiphilic polymers resulted in lower color-transition
temperature and faster color-transition. Also, higher temperature led to faster color-transition. The colorchanging
of PDA/amphiphilic polymermatrixmay have resulted from the higher temperature and gradual
insertion of amphiphilic polymer into PDA, synergistically perturbing the conformation of PDA. The prepared
PDA/F127, PDA/F68, PDA/L35 and PDA/Tween-20 aqueous matrix showed potential application in
time–temperature chromatic sensors at around 10–50 ◦C. This work provides a new method to design
time–temperature chromatic sensors.