Abstract. Non-rigid image registration (NIR) is an essential tool for
morphologic comparisons in the presence of intra- and inter-individual
anatomic variations. Many NIR methods have been developed, but are especially
difficult to evaluate since point-wise inter-image correspondence
is usually unknown, i.e., there is no “Gold Standard” to evaluate performance.
The Non-rigid Image Registration Evaluation Project (NIREP)
has been started to develop, establish, maintain, and endorse a standardized
set of relevant benchmarks and metrics for performance evaluation
of nonrigid image registration algorithms. This paper describes the basic
framework of the project