the Cohen’s d approach to calculating effect size was used, where effect size d was defined as the difference between the two mean changes from baseline (i.e., SJW or SAM-e change minus the placebo change) divided by the pooled standard deviation for those mean changes the pooled standard deviation was derived by taking the square root of the mean of the two squared standard deviations at endpoint If variance was presented as standard errors (SE), the SE was converted to standard deviation to allow for determination of the effect size. Evaluation of Behavioral-related Safety/Tolerability the objective of this assessment was to informally assess whether SJW or SAM-e may produce suicidal or other behavioral changes thought to represent potential precursors of suicidal