Causes of nephrotic syndrome
Most children with nephrotic syndrome have what doctors call "minimal change disease". This means their kidneys will appear normal or nearly normal if a tissue sample was studied under a microscope. The cause of minimal change disease is unknown.
Sometimes, nephrotic syndrome can occur as a result of a kidney problem or another condition, such as:
• glomerulosclerosis (when the inside of the kidney becomes scarred)
• glomerulonephritis (inflammation inside the kidney)
• an infection such as HIV, hepatitis or syphilis
• lupus
• diabetes
• sickle cell anaemia
• certain types of cancer, such asleukaemia, multiple myeloma or lymphoma
These problems tend to be more common in adults with nephrotic syndrome.
Congenital nephrotic syndrome is usually caused by an inherited faulty gene. For the condition to be passed on to a child, both parents must have a healthy copy of the gene and a faulty one. This means they don’t have nephrotic syndrome themselves, but there is a one in four chance that any children they have will develop the condition
Causes of nephrotic syndrome
Most children with nephrotic syndrome have what doctors call "minimal change disease". This means their kidneys will appear normal or nearly normal if a tissue sample was studied under a microscope. The cause of minimal change disease is unknown.
Sometimes, nephrotic syndrome can occur as a result of a kidney problem or another condition, such as:
• glomerulosclerosis (when the inside of the kidney becomes scarred)
• glomerulonephritis (inflammation inside the kidney)
• an infection such as HIV, hepatitis or syphilis
• lupus
• diabetes
• sickle cell anaemia
• certain types of cancer, such asleukaemia, multiple myeloma or lymphoma
These problems tend to be more common in adults with nephrotic syndrome.
Congenital nephrotic syndrome is usually caused by an inherited faulty gene. For the condition to be passed on to a child, both parents must have a healthy copy of the gene and a faulty one. This means they don’t have nephrotic syndrome themselves, but there is a one in four chance that any children they have will develop the condition
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