The methylation status of the promoter is a
key mechanism regulating galectin-1 expression [22,23] Furthermore,
several transcription factors are implicated in galectin-1
expression such as hypoxia inducible factor-1 (HIF-1) in colorectal
cancer cells [24], nuclear factor j B (NFjB) in T cells [25] and
Kaposi’s sarcoma [26], activator protein 1 (AP1) in classical Hodgkin
lymphoma Reed-Sternberg cells [27] and CAAT/enhancer binding
prot a (C/EBPa) in acute myeloid leukemia [28].