: Male Wistar rats were orally given the alcoholic extract of Bacopa monnieri at
doses of 20, 40 and 80 mg/kg BW via feeding needle for a period of 2 weeks before and 1 week after
the intracerebroventricular administration of AF64A bilaterally. Rats were tested for spatial memory
using Morris water maze test and the density of neurons and cholinergic neurons was determined using
histological techniques 7 days after AF64A administration.