Main Results
Four randomized studies were included, 2 with parallel group and 2 with
split-mouth designs. All children were aged 5 to 9 years at baseline. Only
permanent first molars were sealed in all 4 studies. Follow-up generally
was for 1 to 2 years, with one study longer. Data were not combined, and
no meta-analysis was conducted because of the substantial methodological
differences across studies.