The folding rate ln(kf) as calculated from FOLRATE for Bcl-2 showed that the rate of a and b type folding are 19.5/sec and
7.54/sec. CDK-4/Cyclin D1 exhibited 13.9/sec and 21.0/sec as the folding rate of a, b types for chain A and a rate of -0.319/sec and 12.2/sec for chain B respectively. Amino acid compositions for the two proteins including the a, b type compositions (Table S7) during their folding pattern along with the residue positions are shown in Table S2. This composition shows slight variation for proteins of different sub cellular regions.