Glass is an amorphous, non-crystalline, more or less transparent material. Self-cleaning glass is a special types of glass that needs minimal maintenance because its surface has been designed to keep itself free from dirt and grime. Nanotechnology is used for the fabrication of this special glass in which an ultra-thin coating is applied to achieve the self-cleaning property. Self-cleaning glass is of two types: hydrophilic and hydrophobic. In the former, a tiny coating of titania is used and in the latter a thin layer of silica coating is applied through nanotechnology. Glare-free glass that does not fog has the benefit of preventing spectacles from misting up when the wearer is drinking a hot beverage in winter. Additionally, it enables tablet computers to be used near swimming pools and minimizes the amount of cleaning needed for glass windows and doors. The history, types, methods of fabrication, mechanics, advantages and disadvantages of self-cleaning glass is the subject of this chapter.