Results
Heart rates and blood pressure-Table I shows the mean sitting,
standing, exercise, and postexercise heart rates and systolic and
diastolic blood pressures at four, 12, and 24 hours after dosing for
the four treatments. Values for the least significant differences at the 50°, level are included and indicate the smallest difference between
any pair of means that would be declared significant at the 5% level.
Each value is appropriate for any of the six pairs of differences that
can be selected from the four means. The use of least significant
differences rather than standard errors of means allows for direct
interpretation of clinically relevant differences between treatments.
Heart rate and systolic blood pressure-Four and 12 hours after
dosing the mean values of these two variables were similar in each
position for all treatments. At 24 hours after dosing the effects of
both doses of atenolol were similar. Comparisons of the four treatments
favoured atenolol (table II).
Diastolic blood pressure-No significant differences were evident
between the treatments in diastolic blood pressure in any position
at any of the times measured.
Blood concentrations-Table III shows blood concentrations of
the drugs four, 12, and 24 hours after dosing for the four treatments.
In each case the concentrations were correlated with the dose
administered.