Efforts to implement pre-exposure prophylaxis (PrEP) to priority target populations throughout the U.S. will require strategic planning, politicalwill, and collaborative partnerships between primary care and public health. Work in other health areas1–6 and models2,7 of linkages between primary care and public health provide both guidance and examples that may be
adapted readily to PrEP delivery. Moreover, a recent IOM report8 provides a road map for integrating primary care and public health to improve population health.