We conducted a qualitative research study using semi-structured interviews and focus-group discussions in August and September 2011. We examined patients’ opinions, views and experiences of home-based treatment and care for MDR-TB versus their assertions of care in hospital. We also identified how these views compared with those of their families and other stakeholders involved with TB. These methods were chosen due to the exploratory nature of the research question, with interviews allowing an in-depth view to the opinions and experiences of respondents, and focus-group discussions showing group dynamics and general consensus versus anomalies regarding this topic. The principal investigator did not occupy the dual role of clinician and researcher, and therefore maintained a level of independence to reduce study bias.