FFFAs are known inducers of ANGPTL4 expression and previous studies have suggested that an increase in intestinal ANGPTL4 may result in blocking of adipocyte-associated LPL activity, thereby preventing uptake of FFA in adipose tissues (B€ackhed et al., 2004). Elevated levels of lipids in the blood stream may then occur. However, Mattijssen et al. (2013) presented data indicating that ANGPTL4 may inhibit the pancreatic lipase, hence limiting uptake of lipids from the intestine. The role of ANGPTL4 in lipid