Large number of investigations have provided the evidence that type 1 and type 2 diabetes increase the risk
and severity of periodontitis, and vice versa periodontitis has been shown to have impact on diabetic status
by using rodent studies although the underlying mechanism has not been discussed.
The association between diabetes mellitus and periodontal disease is therefore considered to be bidirectional: diabetes as a risk factor for periodontitis and periodontitis as a possible severity for diabetes.
In fact, aggressive periodontitis is recognized as the sixth serious complication of diabetes.