Niosomes
are
lamellar
vesicles
prepared
from
non-ionic
sur-
factants
such
as
sorbitan
fatty
acid
esters
(Span),
polysorbates
(Tween),
and
polyethoxy
fatty
ethers
(Brij).
Compared
with
phospholipid-based
vesicles,
niosomes
have
a
low
cost
of
produc-
tion,
a
higher
chemical
stability,
and
a
larger
membrane
flexibility.
These
characteristics
make
niosomes
an
ideal
vehicle
for
transder-
mal
delivery
of
various
drugs
(Hamishehkar
et
al.,
2013).
Despite
the
above
merits,
niosomes
still
have
some
disadvantages
shared
with
other
liposomes.
Dispersed
in
an
aqueous
medium
niosomes
on
a
long
storage
suffer
from
hydrolysis
and
degradation.
They
often
undergo
sedimentation,
aggregation
or
fusion.
Proniosome
gel
for-
mulation,
a
gelified
ethanolic
non-ionic
surfactant
that
transforms
into
niosome
upon
hydration,
can
be
an
alternative
to
overcome
these
problems
Niosomes are lamellar vesicles prepared from non-ionic sur- factants such as sorbitan fatty acid esters (Span), polysorbates (Tween), and polyethoxy fatty ethers (Brij). Compared with phospholipid-based vesicles, niosomes have a low cost of produc- tion, a higher chemical stability, and a larger membrane flexibility. These characteristics make niosomes an ideal vehicle for transder- mal delivery of various drugs (Hamishehkar et al., 2013). Despite the above merits, niosomes still have some disadvantages shared with other liposomes. Dispersed in an aqueous medium niosomes on a long storage suffer from hydrolysis and degradation. They often undergo sedimentation, aggregation or fusion. Proniosome gel for- mulation, a gelified ethanolic non-ionic surfactant that transforms into niosome upon hydration, can be an alternative to overcome these problems
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