Background: Domperidone is commonly used off-label to stimulate milk production in mothers who have low milk supply. The aim of
this study was to describe trends, patterns and determinants of postpartum domperidone use.
Methods: This is a retrospective, population-based study involving all women with a live birth between Jan. 1, 2002, and Dec. 31,
2011, in the province of British Columbia. We examined administrative data sets containing person-specific information on filled prescriptions
and use of medical services, and we used logistic regression to examine associations between domperidone use and
maternal characteristics.
Results: The study population consisted of 225 532 women with 320 351 live births. The prevalence of postpartum domperidone use
more than doubled between 2002 and 2011. In 2011, 1 in 3 women with a preterm birth and 1 in 5 women with a full-term birth were prescribed
domperidone in the first 6 months postpartum. Women who were older, had a higher body mass index, had a chronic disease,
were first-time mothers, delivered more than 1 baby (multiple pregnancy), had a preterm birth or had a cesarian delivery were more
likely to fill a postpartum domperidone prescription.
Interpretation: We found an increase in postpartum domperidone use over a 10-year period. More research is needed on maternal
and infant health outcomes.