PROM with GBS
The 2009 Cochrane review included women with ruptured membranes. In this setting, there was some evidence of less chorioamnionitis (RR 0.66, CI 0.47 to 0.92) and use of antibiotics in the neonatal period with the use oxytocin alone than with vaginal PGE2.99 The authors stated the data should be viewed with caution because the infection had not been not pre-specified. In the setting of term PROM and GBS, the Term PROM trial showed that GBS colonization was predictive of neonatal infection for induction with vaginal PG (OR 5.13, 95% CI 2.54 to 10.37) and in expectant groups (OR 4.12, 95% CI 2.00 to 8.52) but not in the group induced with oxytocin.100