Predominant temperament models propose that negative (NEM) and positive emotionality (PEM) contribute to affective reactivity while effortful control (EC) comprises the capacity to regulate and control these affective responses. Considerable research indicates that negative constitutes a potent affective temperamental risk to depression [50]. Likewise, lower PEM, including disrupted reward functioning, predicts later depression [51], and this effect may increase through the pubertal transition [52 and 53]. Poor EC, as a main effect, also predicts later depression [13]. Importantly, EC also synergistically interacts with the affective temperament components to contribute to depression risk, such that high NEM, low PEM, and low EC related to high depressive symptoms [54].