In order to better comprehend the results of this systematic review, the main features of the included injury models are described below. Currently, several neurotoxins are available to induce experimental parkinsonism in animals. In this review, the four most frequently utilized methods are included, since they are generally considered as the best validated models. All four of these neurotoxins are capable of inducing the pathological hallmark of PD, neuronal cell loss in the substantia nigra (SN) [14]. The main contributing factor to this cell loss is mitochondrial dysfunction by inhibiting complex I, resulting in oxidative stress and eventually cell death (Fig. 1) [15].
In order to better comprehend the results of this systematic review, the main features of the included injury models are described below. Currently, several neurotoxins are available to induce experimental parkinsonism in animals. In this review, the four most frequently utilized methods are included, since they are generally considered as the best validated models. All four of these neurotoxins are capable of inducing the pathological hallmark of PD, neuronal cell loss in the substantia nigra (SN) [14]. The main contributing factor to this cell loss is mitochondrial dysfunction by inhibiting complex I, resulting in oxidative stress and eventually cell death (Fig. 1) [15].
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