The main challenge addressed by this work is to evaluate the feasibility of designing a self-medication application relying on the LOD. Open Self-Medication is a proof of concept that such an application can be implemented and, considering positive feedbacks from end-users, can provide a useful service to the general public. The main contributions consist in the identification of a subset of the LOD to self-medication and the selection relevant molecules. The latter leverages on research previously conducted over several years on a similar French system, i.e., the design of a self-medication knowledge base and its use in enhancing data quality, [6] form more details.