TH is an antifungal drug (structure shown in Fig. 1). The most frequent adverse effects after oral use are gastrointestinal disturbances such as nausea, diarrhoea, and mild abdominal pain (Sweetman, 2009). Topical administration can avoid its adverse effects, but the limited solubility of TH, both in water and in lipids, makes its have a quite low bioavailability, especially in topical dosage forms.