In an intra-oral caries model system, Chandler et al. (1995) found, in
a preliminary study, that fluoride as NaF and NaMFP did not significantly
reduce the demineralisation due to dietary carbohydrate, when
added to milk which was administered by immersion of experimental,
gauze-covered bovine enamel blocks which were worn in an appliance
in the mouths of human subjects (intra-oral cariogenicity test, ICT).
The number of subjects involved, the intensity of the caries challenge,
and the duration of the experiment were all, however, small