Recommended adjuvant therapy for early-stage ovarian cancer depends
on tumor sub-stage and grade. Two randomized controlled trials
by the Gynecologic Oncology Group (GOG) demonstrated that adjuvant
chemotherapy did not provide a survival benefit in patients with low risk
tumors (stages IA–IB, grades 1–2) . In contrast, patients with
high-risk (stages IA–IB grade 3, stage IC, stage II), early-stage ovarian
cancer appear to benefit from adjuvant chemotherapy