SU use is thought to be associated with a number of safety issues. Rational use of these molecules however can minimize these risk. In meta-analysis mentioned above mild-to-moderate hypoglycaemic episodes were significantly more in the sulfonylurea-treated group than in the comparator groups (RR 2.41%, 95 % CL 1.41, 4.10) none of the trials however reported any severe hypoglycaemic events requiring third-party assistance an increase in weight of 2.31 kg (95 % cl 1.31 3.32) was seen in the sulfonylurea-treated groups compared with comparator groups