The enhanced rate of wound contraction and reduction in healing time in treated rats might be due to the anti-inflammatory effects of this material together with its effect on maturation and organization of the granulation tissue. Another and perhaps signifi cant feature in the treated group was that their newly formed collagen fibers were aligned and were not randomly distributed as in the untreated lesions. The histological appearance indicated a greater degree of organization of the collagen orientation in the treated lesions and a more normal alignment of new collagen, which was strikingly similar to that of the normal
undamaged, skins.