The importance of non-specific defenses against microbial in the case of cultured fishs, wich are inevitably subjected to different stresses like crowding, handling, poor water quality and a constant threat of cultured fishes, which are inevitably subjected to different stresses like crowding, handling, poor water quality and a contant threat of exposure to potential pathogens[5]. For fish disease control, immunostimulants and adjuvants used in fish vaccines are able to act as an alternative to antimicrobial agents like antibiotics used in fish culture.