The effect of regiospecificity of dietary TG bioavailability has
been previously studied (29, 30), indicating a preferential
absorption of FAs when present at the TG sn-2 position.
Moreover, FO functional characteristics seem to be related to the
positional distribution of EPA and DHA on TGs (29, 57). For
example, in a recent study in C57BL/6J mice by Yoshinaga et al.
(29), DHA in the sn-2 position was associated with greater liver
DHA accumulation and serum and liver TG lowering, whereas
EPA in the sn-1 and -3 positions had a greater impact on
lowering hepatic cholesterol concentrations. In the present
study, regiospecific analysis showed similar proportions of
EPA in the sn-2 position of TGs in the CO and FO. This is
consistent with the uniform response of serum lipids and
tissue EPA concentrations reported in mice fed the FO- and
CO-based diets.