Background: Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes.
Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC).
Iron chelators are widely
used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are nontoxic to mammalian cells.