Mixer agglomeration, in particular high shear wet granulation, is a unit operation typically used in the pharmaceutical
industry to improve the flowability, the compressibility, the dosing accuracy during tableting or the content
uniformity of a blend. Thanks to its advantages (production of spherical and dense granules, reduction of
production time), this technique can be potentially successful also in the food industry as for example in the production
of dietary supplements. In this work four thickening agents (povidone, maltodextrin, k-carrageenan and
xanthan gum) have been tested to study their effects on the granule growth behavior and on some technologically
relevant granule properties (size, shape, strength and flowability). Experiments highlighted the full feasibility
of the process and the possibility of using these agents to get products with satisfactory technological
properties. The dependence of product properties on the formulation variables (water and binder amount) has
been analyzed according to a multivariate approach and a robust predictive tool for the granule size has been developed.
Furthermore it was observed that a reduced amount of binding liquid (water) can be used in the
presence of strongly thickening binderswith a reduction up to 25%. Thiswould decrease drying time and energy
requirement and be beneficial especially in the food and food supply industry where products have generally
lower added value than in the pharmaceutical one and reducing production costs is critical.
Mixer agglomeration, in particular high shear wet granulation, is a unit operation typically used in the pharmaceuticalindustry to improve the flowability, the compressibility, the dosing accuracy during tableting or the contentuniformity of a blend. Thanks to its advantages (production of spherical and dense granules, reduction ofproduction time), this technique can be potentially successful also in the food industry as for example in the productionof dietary supplements. In this work four thickening agents (povidone, maltodextrin, k-carrageenan andxanthan gum) have been tested to study their effects on the granule growth behavior and on some technologicallyrelevant granule properties (size, shape, strength and flowability). Experiments highlighted the full feasibilityof the process and the possibility of using these agents to get products with satisfactory technologicalproperties. The dependence of product properties on the formulation variables (water and binder amount) hasbeen analyzed according to a multivariate approach and a robust predictive tool for the granule size has been developed.Furthermore it was observed that a reduced amount of binding liquid (water) can be used in thepresence of strongly thickening binderswith a reduction up to 25%. Thiswould decrease drying time and energyrequirement and be beneficial especially in the food and food supply industry where products have generallylower added value than in the pharmaceutical one and reducing production costs is critical.
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