The current investigation was undertaken on “transmission of resistance to papaya ringspot virus (PRSV)in intergeneric populations of Carica papaya and Vasconcellea cauliflora”. In this study, the three F2popu-lations raised from S1inbreds were screened and the desired male and female plants were selectedfor sibmating. The F2populations of various combinations segregated for susceptibity and resistance topapaya ringspot virus in two different ratios. The cross combination CO 7 × V. cauliflora (CO7V3) exhib-ited a 15:1 ratio (duplicate gene action) and the crosses Pusa Nanha × V. cauliflora (PNV9) and CP 50 × V.cauliflora (CPV23) exhibited 13:3 ratio (inhibitory gene action). The study revealed multi-genic inheri-tance of resistant to PRSV which uniquely exhibit inter-genic interactions.© 2015 Elsevier B.V. All rights reserved