Although 5-FU is the standard chemotherapeutic drug used in the treatment of human cholangiocarcinoma, evidence of 5-FU resistance has been reported both in vitro[9] and in vivo[7].
It has been demonstrated in a previous study [19] that variations in the sensitivity to chemotherapeutic drugs were observed among the five intrahepatic cholangiocarcinoma cell lines and sensitivity to chemotherapeutic drug.