THALASSEMIA, A TERM THAT DEFINES A GROUP OF deficiencies in the production of the - or -globin chain of hemoglobin, is one of the most common single gene disorders in humans. Nearly 60% of the total population is affected in some regions of Thailand, Laos, and Cambodia,1 and although a much smaller prevalence is found in North America (0.1%), its incidence is increasing. More than 200 - and -globin gene mutations have been identified. In its most severe form, individuals with either - (especially hemoglobin H–Constant Spring) or -thalassemia require routine red blood cell transfusions soon after birth for survival.
THALASSEMIA, A TERM THAT DEFINES A GROUP OF deficiencies in the production of the - or -globin chain of hemoglobin, is one of the most common single gene disorders in humans. Nearly 60% of the total population is affected in some regions of Thailand, Laos, and Cambodia,1 and although a much smaller prevalence is found in North America (0.1%), its incidence is increasing. More than 200 - and -globin gene mutations have been identified. In its most severe form, individuals with either - (especially hemoglobin H–Constant Spring) or -thalassemia require routine red blood cell transfusions soon after birth for survival.
การแปล กรุณารอสักครู่..