With respect to efficacy, this review examined whether SJW and SAM-e provide clinically relevant benefit when utilized as antidepressant monotherapy
Whether either product is potentially useful in an augmentation or combination approach along with a conventional antidepressant was not addressed.
Sarris et al, in their review, report that either product, when used in combination with conventional antidepressants, has the potential to enhance response or limit side effects (by allowing lower doses of the conventional antidepressant to be prescribed)