Rapid-cycling bipolar disorder is associated with high morbidity
and poor treatment outcome.
1–7
Some studies suggest an
association between rapid cycling and antidepressant use,
5,7–11
although this has not been universally observed.
12–18
Controlled
trials have reported good efficacy and low mood conversion rates
during antidepressant use in bipolar II disorder.
13,15,16,19–21
We
performed an exploratory analysis of a randomised, double-blind,
placebo-controlled trial to examine the efficacy and mood
conversion rate of long-term fluoxetinev.lithium monotherapy in
patients with rapid-v.non-rapid-cycling bipolar II disorder who
recovered from a major depressive episode during initial fluoxetine
monotherapy (trial registration NCT00044616). We hypothesised
that lithium monotherapy would provide greater relapse prevention
with fewer treatment-emergent mood conversion episodes in
patients with rapid-v.non-rapid-cycling bipolar II disorder
Rapid-cycling bipolar disorder is associated with high morbidity
and poor treatment outcome.
1–7
Some studies suggest an
association between rapid cycling and antidepressant use,
5,7–11
although this has not been universally observed.
12–18
Controlled
trials have reported good efficacy and low mood conversion rates
during antidepressant use in bipolar II disorder.
13,15,16,19–21
We
performed an exploratory analysis of a randomised, double-blind,
placebo-controlled trial to examine the efficacy and mood
conversion rate of long-term fluoxetinev.lithium monotherapy in
patients with rapid-v.non-rapid-cycling bipolar II disorder who
recovered from a major depressive episode during initial fluoxetine
monotherapy (trial registration NCT00044616). We hypothesised
that lithium monotherapy would provide greater relapse prevention
with fewer treatment-emergent mood conversion episodes in
patients with rapid-v.non-rapid-cycling bipolar II disorder
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