Public funders,philanthropic institution, pharmaceutical companies and biotech companies all play a role in the research and development (R&D) of new vaccines.A WHO-UNICEF analysis eatimated that US$76 billion was required for immunisation strategies for 2006 to 2015 among 117 low- and middle-income countries alone. Although,since 2000, international financing of global health has increased substantially; the Global Immunisation Vision and Strategy for 2006-2015 is under funded by US$11-15 billion. Since 2007, R&D expenditures have been estimated for global neglected diseases.Arecent study, which reviewed 6170 studies accounting for £2.6 billion of investments, documented for the first time in detail research investment for infectious diseases in the UK or for the UK institution and the global partners involved in infectious disease research. However, annual expenditures on vaccine research have not been estimated. The United Kingdom(UK) is the second largest inverstor in global health; however, there are no analyses of R&D funding allocated to vaccine research and delivery. Investments by the UK pharmaceutical industry are also poorly documented, primarily due to commercial sensitivity of the data on R&D funding. In this study, we systematically analyse the financing for vaccine research and immunology of infectious diseases.