It was shown that curcumin influences a wide range of membrane proteins, by modulating the properties of the hoslipid bilayer [22,23]. As the HA protein is expressed on the envelope of the influenza virus, it is worthwhile to explore whether curcumin’s inhibitory effect is only on the HA activity of the influenza virus or it is deleterious to membrane proteins of other viruses. In this work, the effects of curcumin on the infectivity of several viruses were investigated and their potential underlying mechanisms were also discussed.