likely to be involved during progression of pancreatic
-cell dysfunction. Because of the relatively low expression of
antioxidant enzymes such as catalase (CAT) and super dxide
dismutase (SOD) in diabetes, pancreatic -cells may be
vulnerable to ROS attack when the system is under oxidative
stress situation. Similarly, elevated levels of free radicals,
due to inefficiency of the antioxidant defense system, may
lead to disruption of cellular function by enhancing the
susceptibility of membranes to lipid peroxidation[3].