The prevalence of disease and culling rates is high in the
periparturient period of high-yielding dairy cows (Drackley, 1999).
Periparturient cows were shown to display an inflammatory response
related to pregnancy and lactation (Sordillo et al., 2009). Such an inflammatory
response is characterized by negative and positive acute
phase protein (APP) responses in the first month of lactation (Bertoni
et al., 2006). Although APP signals cows at risk in the post-calving period,
we felt that a practical, “robust” and user-friendly prediction system
was absolutely needed in the dry period. Our working hypothesis implied
that stressful events in the dry period could give rise to a negative
imprinting of the innate immune system, underlying a defective
homeostatic control of the physiological inflammatory response after
calving, and the occurrence of serious disease cases. Thus, an ad hoc
field trialwas set up to verify our tenet under field conditions. In particular,
innate immune responses and parameters of metabolic stress in
the dry period were offset against occurrence of disease cases and
culling in the early lactation period.
The prevalence of disease and culling rates is high in theperiparturient period of high-yielding dairy cows (Drackley, 1999).Periparturient cows were shown to display an inflammatory responserelated to pregnancy and lactation (Sordillo et al., 2009). Such an inflammatoryresponse is characterized by negative and positive acutephase protein (APP) responses in the first month of lactation (Bertoniet al., 2006). Although APP signals cows at risk in the post-calving period,we felt that a practical, “robust” and user-friendly prediction systemwas absolutely needed in the dry period. Our working hypothesis impliedthat stressful events in the dry period could give rise to a negativeimprinting of the innate immune system, underlying a defectivehomeostatic control of the physiological inflammatory response aftercalving, and the occurrence of serious disease cases. Thus, an ad hocfield trialwas set up to verify our tenet under field conditions. In particular,innate immune responses and parameters of metabolic stress inthe dry period were offset against occurrence of disease cases andculling in the early lactation period.
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