well-established natural antioxidant agent, butits poor water-solubility, low chemical
stability and low bioavailability limitits application in food, pharmaceuticals and cosmetics industries.
Thus itis criticalto develop an efficient method to improve the water solubility and stability of -C. In this
research, amphiphilic chitosan-graft-poly (lactide) (CS-g-PLA) copolymer was synthesized via a homogeneous
ring-opening polymerization (ROP) in ionic liquid. The obtained CS-g-PLA copolymer was able to
self-assemble into about 14 nm micelles in water at low concentration, and -C loaded micelles (-C/M)
had low -C degradation after 15 days. The antioxidant properties of the -C/M were investigated by the
2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method,
respectively. Significantly improved antioxidant activity was observed for -C/M in compare with free
-C. The aqueous dispersion of -C/M has potential to be applied in the field of functional food and
cosmetics.
well-established natural antioxidant agent, butits poor water-solubility, low chemicalstability and low bioavailability limitits application in food, pharmaceuticals and cosmetics industries.Thus itis criticalto develop an efficient method to improve the water solubility and stability of -C. In thisresearch, amphiphilic chitosan-graft-poly (lactide) (CS-g-PLA) copolymer was synthesized via a homogeneousring-opening polymerization (ROP) in ionic liquid. The obtained CS-g-PLA copolymer was able toself-assemble into about 14 nm micelles in water at low concentration, and -C loaded micelles (-C/M)had low -C degradation after 15 days. The antioxidant properties of the -C/M were investigated by the2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method,respectively. Significantly improved antioxidant activity was observed for -C/M in compare with free-C. The aqueous dispersion of -C/M has potential to be applied in the field of functional food andcosmetics.
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