Goals of early goal-directed therapy: central
venous pressure and central venous oxygen
saturation
Recently, three large randomized controlled trials enrolling
a total of 4,183 patients were completed to reexamine
the effect of early goal-directed resuscitation on
outcomes in patients with septic shock: the Protocolized
Care for Early Septic Shock (ProCESS) trial in the United
States, the Australasian Resuscitation in Sepsis Evaluation
(ARISE) trial, and the Protocolised Management of Sepsis
(ProMISe) trial in England (Table 2). Each trial used
inclusion criteria similar to the original study by Rivers
and colleagues and was powered to detect a 6 % to 8 %
absolute mortality reduction