Abstract
The arbutin loaded chitosan nanoparticles were prepared by ionotropic gelation technique.
Variations in chitosan concentration, pH of chitosan solution, volume ratios of chitosan/tripolyphosphate
and weight ratios of arbutin/chitosan were systematically examined for their effect on the physicochemical
properties of the nanoparticles which were characterized by the zeta sizer and transmission electron
microscope (TEM). These nanoparticles presented high arbutin loading efficiency. The entrapment
efficiency increased with increasing arbutin/chitosan weight ratios. This study demonstrated that
complexation between chitosan and TPP forms stable cationic nanoparticles for subsequent arbutin loading.