Results
Percentage of dysplasia and cancer
36 H&E-stained slides from rats under 4 different treatment conditions were examined under light microscopy to check for dysplasia and carcinoma (Table 1). No rats from the control or MRN-100-treated group developed dysplasia or carcinoma. On the other hand, rats from the carcinogen-treated group and the carcinogen plus MRN-100 group developed dysplasia and carcinoma. Rats treated with only carcinogen showed 90% (9/10 rats) development of either single or multiple (≥2) foci. In contrast, of rats treated with carcinogen plus MRN-100 only 40% (4/10) carried foci. Moreover, only 10% (1/10) of MRN-100-treated rats developed multiple foci as compared to 20% (2/10) in the carcinogen group (Table 2).