During our ongoing search for new bioactive compounds from
fungi,14–17 the extract of the fungus Cladosporium cladosporioides,
isolated from the sediment of the hypersaline lake El Hamra located in
Wadi el Natrun (Egypt), caused complete growth inhibition of the
murine lymphoma cell line L5178Y when assayed at a dose of
10 μg ml− 1. Bioassay-guided fractionation of the extract afforded a