Some studies reported that isoquinoline alkaloid reach fraction from stem, including pamatine, jatrorrhizine,
and magnoflorine of T. cordifolia have been reported for insulin mimicking and insulin releasing effect both in vitro and in vivo.[38] Oral treatments of root extracts have been reported to regulate blood glucose levels, enhance insulin secretion and suppress OS markers. Initiation and restoration of cellular defense antioxidant markers including superoxide dismutase, glutathione (GSH) peroxidase and GSH, inhibition of glucose 6-phosphatase and fructose 1, 6-diaphosphatase, restoration of glycogen content in liver were reported in vitro studies.[38] The crude stem ethyl acetate, dichloromethane, chloroforms and hexane extracts of T. cordifolia inhibited the enzymes salivary and pancreatic amylase and glucosidase[39] thus increase the postprandial glucose level and finds potential application in the treatment of diabetes mellitus.[40]