Anti-hyperglycemic Activity
Glucose tolerance property of methanol extract of Madhuca indica leaves and Paederia foetida stems was
determined as per the procedure previously described by Joy and Kuttan (1999) with minor modifications. In
brief, for Madhuca indica leaves, fasted mice were grouped into six groups of six mice each. The various
groups received different treatments like Group-I received vehicle (1% Tween 80 in water, 10 ml/kg body
weight) and served as control, group-II received standard drug (glibenclamide, 10 mg/kg body weight) and the
other four groups (III-VI) received the methanol extract of Madhuca indica leaves at four different doses of
50, 100, 250 and 500 mg/kg body weight. Each mouse was weighed and doses adjusted accordingly prior to
administration of vehicle, standard drug, and test samples. All substances were orally administered. Following
a period of one hour, all mice were orally administered 2 g glucose/kg of body weight. Blood samples were
collected two hours after glucose administration through puncturing heart.