Many endophytes locally infect plant parts, being restricted to a small tissue area. This is supported by the fact that often, several endophytic species are recovered from different fragments of the same plant. In contrast, Neotyphodium and Epichloë species systemically infect the intercellular space of leaves, reproductive stems, and seeds of their hosts These
systemic endophytes can be isolated from multiple fragments of the same plant. Tissue and organ specificity also occurs, and some endophytes may be found in specific plant parts such as roots, leaves, or twigs, while others may infect several of these parts