To evaluate the drug-modifying effect of HELZJ in combination with antibiotics, different classes of antibacterial agents were used (amoxicillin, ciprofloxacin, penicillin G, gentamicin, amikacin and vancomycin). With regard to the influence of HELZJ on antifungal activity, three drugs were used: mebendazole, benzoyl metronidazole and nystatin.